In this talk Dr. Hamid Bolouri of the Institute for Systems Biology will briefly describe methodologies and tools they have developed for predicting protein DNA interactions (Mogul), statistical integration of different types of data (Pointillist), network visualization (BioTapestry), and network simulation (Dizzy). Furthermore, he will describe the application of these tools to reverse engineering the signaling and transcriptional networks underlying the response of mouse macrophages to pathogens.