Stanford Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Physical chemistry and machine learning meet innate immunity"

Thursday, March 9, 2017

12:00 pm

Clark Center Seminar Room S360 Map

Sponsored by:
Bio-X Program

Frontiers in Interdisciplinary Biosciences Seminar

Speaker: Gerard Wong, Professor of Bioengineering and of Chemistry & Biochemistry, UCLA

Seminar Title: "Physical chemistry and machine learning meet innate immunity"

Hosted by: Bo Wang, Department of Bioengineering

Abstract:



Biomolecular self-assembly can play unexpected roles in infectious diseases and immunity. It is a commonplace notion that specific binding plays critical roles in the immune system. Here, we explore how one can construct exquisitely specific interactions using non-specific interactions. Specifically, we will discuss how organization of immune ligands impacts immune activation via Toll-Like Receptors, the surprising role played by innate immunity peptides in this organization, and how these effects are at play in inflammation induced by heart disease, necrotic cell death, neutrophil extracellular traps, and autoimmune diseases. We will also discuss how machine learning can be used to map out the undiscovered sequence space of antimicrobial peptides, and how this knowledge may be used to create new molecules against multi-drug resistant pathogens by renovating existing obsolete antibiotics.

When:
Thursday, March 9, 2017
12:00 pm – 1:05 pm
Where:
Clark Center Seminar Room S360 Map
Tags:

Seminar Science 

Audience:
Faculty/Staff, Students
Contact:
650-725-7472, chuber@stanford.edu
More info:
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