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Stanford Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Physical chemistry and machine learning meet innate immunity"
Frontiers in Interdisciplinary Biosciences Seminar
Speaker: Gerard Wong, Professor of Bioengineering and of Chemistry & Biochemistry, UCLA
Seminar Title: "Physical chemistry and machine learning meet innate immunity"
Hosted by: Bo Wang, Department of Bioengineering
Biomolecular self-assembly can play unexpected roles in infectious diseases and immunity. It is a commonplace notion that specific binding plays critical roles in the immune system. Here, we explore how one can construct exquisitely specific interactions using non-specific interactions. Specifically, we will discuss how organization of immune ligands impacts immune activation via Toll-Like Receptors, the surprising role played by innate immunity peptides in this organization, and how these effects are at play in inflammation induced by heart disease, necrotic cell death, neutrophil extracellular traps, and autoimmune diseases. We will also discuss how machine learning can be used to map out the undiscovered sequence space of antimicrobial peptides, and how this knowledge may be used to create new molecules against multi-drug resistant pathogens by renovating existing obsolete antibiotics.