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Stanford Bio-X Frontiers in Interdisciplinary Biosciences Seminar, "Off the Clock: Circadian-Regulated Physiologies and Disease"
Frontiers in Interdisciplinary Biosciences Seminar
Speaker: Mimi Shirasu-Hiza, Columbia University
Seminar Title: "Off the Clock: Circadian-Regulated Physiologies and Disease"
Hosted by: Drs. Aaron Straight (Biochemistry) and David Schneider (Microbiology & Immunology)
Abstract: Circadian regulation is composed of daily, 24-hour oscillations in biological functions and is a universal, evolutionarily conserved feature from bacteria to humans. Proper circadian regulation is fundamental to human health: chronic disruption of circadian regulation due to jetlag or night shift work is associated with multiple defects in innate immunity and metabolism. Many disease states also cause loss of circadian regulation, including neurological disorders (i.e., Alzheimer’s disease, Parkinson's disease, and autism), bacterial infection, and aging. What remains unclear is how loss of circadian regulation contributes to the progression of these diseases. Using the fruit fly as a model organism, the Shirasu-Hiza lab studies circadian-regulated physiologies in the context of disease to understand underlying pathological mechanisms and to identify new potential therapeutic targets.