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BioE 393 Seminar | Kim Sneppen - "A Dynamic Perspective on Epigenetics in Cis"
Cells can be in different states of gene expression states. These states are universally maintained by positive feedback mechanisms. A subset of these states is formed by nucleosomes that recruit “read-write” enzymes which in turn modify other nucleosomes. This opens for a level of local genetic regulation which can maintain genes primed for regulation by external factors. I discuss possible rules for such dynamics, with particular emphasis on the interplay between read-write processes that act locally and the need for some that act on longer distances along the genome. Local epigenetic states of a promoter are sometimes also associated to the methylation status of nearby CpG islands. These appear to be most programmable when they are of intermediate sizes. We argue that methylation, respective un-methylated states of CpG islands must be maintained dynamically.
Professor Kim Sneppen is leader of the Center for Models of Life at the Niels Bohr Institute in Copenhagen. With background in nuclear physics, statistical mechanics, and complex systems, he published papers on punctuated equilibrium in evolution, on genetic networks, on epigenetics and on phage biology. Recent ideas suggest new approaches to understand influenza epidemics, an extension of the competitive exclusion principle in food-webs, as well as a new perspective on DNA methylation in the human genome. Overall Dr. Sneppen plays with models on different scales of life, to learn about ways that life opens options for more life.
Dr. Sneppen got his PhD in nuclear physics from Copenhagen University in 1989. His first permanent position was as professor at the Norwegian University of Science of Technology in 2001. He returned to Copenhagen University at the Niels Bohr Institute in 2002. In 2005 Dr. Sneppen established the Center for Models of Life at the Niels Bohr Institute.
- Monday, March 20, 2017
12:30 pm – 1:30 pm
- Clark Center Room S362 Map
The seminar series for the Department of Bioengineering. Topics and presentors change weekly.
- Faculty/Staff, Students, Alumni/Friends