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BioE 393 Seminar | Christina Fan, Ph.D. "Stochastic labeling of cells and molecules for high throughput single cell analysis: From idea to commercialization"
Most genomics studies in the past have been conducted using nucleic acids isolated from bulk samples, thus masking the contribution from individual cells. Single cell genomics studies have been challenging because of the lack of practical, technically simple method to examine content of large number of cells simultaneously.
Here, I will describe a high throughput single cell gene expression profiling system, named BD Resolve, that we started developing at Cellular Research (now BD Genomics), with the aim to make single cell genomic techniques more accessible to the community. The technique is based on stochastic labeling of cells and molecules, using an array of picoliter microwells and barcoded bead reagents. I will go over several applications, such as analysis of blood cells from diseased and healthy individuals, and cells obtained from bronchoalveolar lavage samples.
I will also describe the 4 year journey from idea generation and proof of principle in a small startup environment to full blown commercialization of the technology.
Christina Fan received her Ph.D. in Bioengineering from Stanford University in 2011, under the guidance of Dr. Stephen Quake. As a graduate student, she developed innovative genomic technologies and clinical applications of emerging genomic technologies. She co-invented with Dr. Quake a noninvasive maternal blood test for fetal aneuploidy and a technique to determine the fetal genome from maternal blood. The former is now a widely used prenatal screening test for genetic diseases including Down syndrome. Her research has been published in reputable journals including Nature, Science and Cell, and has received recognitions such as TR10 by MIT’s Technology Review. She was a recipient of Forbes 30 under 30 in Science and Innovation two years in a row, and MIT’s Technology Review TR35. Since graduation she has worked in two Silicon Valley startup companies in genomic technologies. The later one was acquired by Becton Dickinson & Company, where she is currently the scientific lead in the area of single cell genomics.
- Monday, April 24, 2017
12:30 pm – 1:30 pm
- Clark Center Room S361 Map
The seminar series for the Department of Bioengineering. Topics and presentors change weekly.
- Faculty/Staff, Students, Alumni/Friends