Intrinsic plasticity and engram formation in neural circuits - Christian Hansel

Thursday, January 11, 2018

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Intrinsic plasticity and engram formation in neural circuits

Christian Hansel, Ph.D

Professor, Departmeent of Neurobiology, The University of Chicago, Chicago, IL

Host: Lu Chen

Abstract

Synaptic plasticity (e.g. long-term potentiation; LTP) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams (“engram cells”). In this presentation, I will argue that ensemble integration may result from LTP, but also from cell-autonomous changes in membrane excitability. I propose that synaptic plasticity determines connectivity maps, whereas intrinsic plasticity — possibly separated in time — amplifies neuronal responsiveness and acutely drives engram integration. This proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.

When:
Thursday, January 11, 2018
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Seminar Science 

Audience:
Faculty/Staff, Students
Contact:
650-497-8019, neuroscience@stanford.edu
More info:
Visit this website