Making Memories Last: Genes, Neurons and Synapses - Kelsey Martin

Thursday, March 8, 2018

3:30 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Making Memories Last: Genes, Neurons and Synapses

Kelsey Martin, MD, Ph.D

Professor of Biological Chemistry and Psychiatry and Dean of the Medical School, David Geffen School of Medicine at UCLA

Host: Jennifer Raymond

Abstract

My lab is interested in understanding the cell biological mechanisms by which experience alters the connectivity of neurons in the brain to store long-term memories. We study long-lasting forms of synaptic plasticity that require changes in gene expression for their persistence. The remarkable polarity and compartmentalization of neurons poses two central challenges to the regulation of gene expression during neuronal plasticity. First, the requirement for new transcription means that signals are relayed the long distance from the synapse to the nucleus to alter RNA synthesis. Second, the fact that synaptic plasticity can be synapse-specific—i.e. that experience-dependent changes can occur at some but not all synapses made by a single neuron—indicates that experience-dependent gene expression can be spatially regulated at the level of synapses. In the first part of my talk, I will describe our studies of synapse to nucleus signaling pathways that regulate transcription. The second part of my talk will focus on post-transcriptional regulation in the cytoplasm through mRNA localization, mRNA stability and local translation.   

When:
Thursday, March 8, 2018
3:30 pm – 4:30 pm
Where:
Clark Center Auditorium Map
Tags:

Seminar Science 

Audience:
Faculty/Staff, Students
Contact:
650-497-8019, neuroscience@stanford.edu
More info:
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