Molecular, cellular, and circuit mechanisms that link memories across time - Alcino Silva

Thursday, March 22, 2018

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Molecular, cellular, and circuit mechanisms that link memories across time

Alcino Silva Ph.D

Distinguished Professor, Psychology, Behavioral Neuroscience, Brain Research Institute, UCLA

Host: Lu Chen

Abstract

Studies of the molecular, cellular and circuit mechanisms of learning and memory have focused almost exclusively on how single memories are acquired, stored and edited. By comparison, very little is known about the mechanisms that integrate and link memories across time. Recent studies from our laboratory showed that learning triggers CREB activation and a subsequent temporary increase in neuronal excitability in these circuits that for a time biases the allocation of a subsequent memory to the neuronal ensemble encoding the first memory. Recently, we have used state of the art in vivo imaging methods and other approaches to show that in the hippocampus, this mechanism can link memories across time, such that the recall of one memory increases the likelihood of recalling the other memory. Interestingly, we also showed that this mechanism is disrupted in older mice, and that artificially manipulating neuronal excitability with a chemo-genetically strategy can rescue these deficits, a result that implicates this mechanism in memory linking and in age-related cognitive decline.

When:
Thursday, March 22, 2018
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Seminar Science 

Audience:
Faculty/Staff, Students
Contact:
650-497-8019, neuroscience@stanford.edu
More info:
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