CHRI Seminar Series - Unraveling the Complex Heterogeneity of Mitochondrial Function Using High-throughput Single Cell Imaging

Monday, August 6, 2018

11:45 am

Li Ka Shing Learning and Knowledge Center, Room #120

Sponsored by:
Child Health Research Institute

About the Seminar

The Stanford Child Health Research Institute presents its next seminar on Unraveling the Complex Heterogeneity of mitochondrial Function Using High-throughput Single Cell Imaging.

Diseases which affect mitochondria are a major cause of pediatric disease, yet our understanding of their mechanisms is incomplete. Until now, methods for assessment of mitochondrial function have required either isolating mitochondria, thus disrupting cell architecture and signaling pathways, or using fluorescent indicators in intact cells, which average measurements over an entire population of cells, eliminating the ability to distinguish cell-to-cell heterogeneity and risking the loss of information. To address this limitation, Dr. Daniel Bernstein and his research team have developed a high-throughput imaging platform that allows them to assess mitochondrial structure and function in individual live cells in real-time, as well as in individual mitochondrial within a single cell. They have uncovered dramatic alterations in mitochondrial function during stress that have been totally missed using prior imaging methods that rely on averaging cell populations. This platform will be useful for the study of myriad diseases where cell heterogeneity may play an important role.

Daniel Bernstein, MD - Dr. Bernstein is the Alfred Woodley Salter and Mabel G. Salter Endowed Professor of Pediatrics and the Associate Dean for Medical Student Curriculum and Scholarship at the Stanford School of Medicine. His recent work has focused on the connection between ß-adrenergic receptors and mitochondrial function and dynamics, and on the molecular mechanisms of right ventricular failure, a critical issue for children with congenital heart disease. He currently is co-PI on Stanford’s NIH/NIAID-funded CTOT multi-center clinical research program, conducting a multi-center clinical trial on biomarkers for post-transplant lymphoproliferative disorders in children. Dr. Bernstein is a recipient of several CHRI awards and serves as a review panel chair for one of the funding programs. 

About the Series

The CHRI Education Seminars highlight compelling clinical topics, innovative research, and the latest developments in maternal child health, and serves as a forum for engaging in conversations with other researchers and scientists across the community. Students, faculty, and postdoctoral researchers are encouraged to attend the seminars. Seats are limited, and reservation is required. Limited lunch will be provided on a first come, first served basis. Attendees are welcome to bring their lunch to the event. Check out more CHRI Education Seminars.

When:
Monday, August 6, 2018
11:45 am – 12:45 pm
Where:
Li Ka Shing Learning and Knowledge Center, Room #120
Admission:

You must register at https://chri-seminar-aug6.eventbrite.com 

Tags:

Lecture / Reading 

Audience:
Faculty/Staff, Students, Members
Contact:
650-498-5444, roxannav@stanford.edu
More info:
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