BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lecture/Presentation/Talk DESCRIPTION:Abstract: Retinal degenerative diseases lead to blindness due t o loss of photoreceptors\, while neurons in the inner retinal layers are st ill preserved. We developed a system substituting the lost photoreceptors w ith photovoltaic arrays. Visual information captured by a camera is project ed onto the subretinal implant from augmented-reality glasses using pulsed near-infrared (880nm) light. Photovoltaic pixels convert this light into el ectric current\, stimulating the second-order retinal neurons\, which then pass visual information through the retinal neural network to the brain. Th is approach preserves many features of natural vision\, simplifies surgery by avoiding bulky electronics and wiring\, allows scaling the number of ele ctrodes to thousands and retains normal association of eye movements with v isual perception. Photovoltaic arrays implanted in patients blinded by age- related macular degeneration provided monochromatic form vision perceived s imultaneously with the remaining peripheral natural vision. Clinical trials with 43 patients across 17 centers in 5 European countries demonstrated le tter acuity matching their 100mm pixel size (20/420). Electronic zoom enabl es patients to read and write smaller fonts\, improving visual acuity\, on average\, by 5 lines of the vision chart – up to 20/63. Decreasing the pixe l size for higher resolution is challenging due to reduced penetration dept h of electric field in tissue. We developed various strategies for shaping the electric field\, including current steering and 3-dimensional electrode s. With this new design\, grating acuity with 40mm pixels in rats matched t he pixel pitch\, while with 20mm\, it reached their natural resolution limi t of 28mm. If successful in clinical trials\, implants with 20mm pixels hav e the potential to increase acuity up to 20/80 without zoom\, and reach 20/ 20 with zoom\, providing highly functional restoration of sight to millions of patients blinded by retinal degeneration.\n\n \n\nDaniel Palanker is a Professor of Ophthalmology and\, by courtesy\, of Electrical Engineering at Stanford University. He received MSc in Physics in 1984 from the Yerevan S tate University in Armenia\, and PhD in Applied Physics in 1994 from the He brew University of Jerusalem\, Israel. Dr. Palanker is working on optical a nd electronic technologies for diagnostic\, therapeutic\, surgical and pros thetic applications\, primarily in ophthalmology. In the field of biomedica l optics\, these studies include interferometric imaging of neural signals and cellular physiology. In the field of electro-neural interfaces\, Dr. Pa lanker is developing retinal prosthesis for restoration of sight to the bli nd and implants for electronic control of organs. Several of his developmen ts are in clinical practice world-wide: Pulsed Electron Avalanche Knife (PE AK PlasmaBlade\, Medtronic Inc.)\, Patterned Scanning Laser Photocoagulator (PASCAL\, Iridex Inc.)\, Femtosecond Laser System for Cataract Surgery (Ca talys\, J&J)\, Neural stimulator for enhanced tear secretion (TrueTear\, Al lergan Inc.). Photovoltaic Retinal Prosthesis (PRIMA\, Pixium Vision) is in clinical trials. DTEND:20260121T003000Z DTSTAMP:20260311T162611Z DTSTART:20260120T233000Z GEO:37.428953;-122.172839 LOCATION:Hewlett Teaching Center\, 201 SEQUENCE:0 SUMMARY:Applied Physics/Physics Colloquium: Daniel Palanker- "Prosthetic Vi sion with a Photovoltaic Substitute for the Lost Photoreceptors" UID:tag:localist.com\,2008:EventInstance_51577446018550 URL:https://events.stanford.edu/event/applied-physicsphysics-colloquium-dan iel-palanker-prosthetic-vision-with-a-photovoltaic-substitute-for-the-lost- photoreceptors END:VEVENT END:VCALENDAR