BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
X-WR-CALNAME:Brain Resilience Seminar: Christine Ng and Selin Jessa
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260520T050043Z
UID:tag:localist.com\,2008:EventInstance_47442932928298
DTSTART:20250203T200000Z
DTEND:20250203T210000Z
DESCRIPTION:The first Monday of each month\, the Knight Initiative for Brai
 n Resilience will host monthly seminars to bring together awardees\, affil
 iated professors and students for a series of 'lab meeting' styled talks. 
 Two speakers will discuss their brain resilience research\, experiences in
  the field\, and answer questions about their work.\n\nTo support our rese
 archers' participation in this open science ‘lab-meeting style’ exchan
 ge of ideas\, these seminars are not streamed/recorded and are only open t
 o members of the Stanford community. \n\nChristine Ng\, Stanford Universit
 y\n\nTargeted Protein Relocalisation - Technology development and opportun
 ities in neurodegeneration\n\nSubcellular protein localisation is crucial 
 for protein function and is commonly disrupted in neurodegeneration. We de
 velop Targeted Relocalisation Activating Molecules (TRAMs) that enable pre
 cise modulation of target protein localisation via shuttle protein couplin
 g. Protein steady-state localisation can be modulated by coupling target p
 roteins with shuttle proteins exhibiting strong localisation sequences and
  appropriate expression levels. We generate scores for relative protein re
 localisability and localisation strength\, highlighting the hierarchy of p
 rotein localisation through various target and shuttle protein combination
 s. We uncover key features that facilitate protein trafficking hijacking a
 nd identify endogenous shuttle proteins with potent ligands suitable for i
 ncorporation into TRAMs\, enabling the relocalisation of endogenous protei
 ns (PRMT9\, SOS1\, FKBP12). TRAMs utilising nuclear hormone receptors as s
 huttles induce nuclear import of mislocalised mutant proteins associated w
 ith neurodegeneration (FUSR495X\, TDP43ΔNLS). Additionally\, FUSR495X can
  be extracted from pre-formed stress granules. TRAM-induced relocalisation
  of NMNAT1 from the nucleus to the axon slows axonal degeneration upon inj
 ury. \n\nThe TRAM approach is being studied on a range of endogenous targe
 ts to probe resultant phenotypic changes and establish general rules. NMNA
 T1 relocalisation in glaucoma mice models is being investigated in collabo
 ration with the Hu lab\, and relocalisation of mislocalised proteins are b
 eing probed in ALS disease models.\n\n \n\nSelin Jessa\, Stanford Universi
 ty\n\nInterpretable machine learning to decipher gene regulation in the br
 ain during development and disease\n\nGene regulation during embryonal dev
 elopment ensures that cells differentiate in the right place and time. Thi
 s process is directed by the binding of sequence-specific transcription fa
 ctors to short DNA sequences\, which drive cell type-specific gene express
 ion. Deciphering this regulation is critical for understanding the etiolog
 y of neurodevelopmental and psychiatric disease\, because genetic variants
  observed in disease often impact these regulatory DNA sequences\, but the
 y are difficult to causally link to disease.\n\nWe combine single-cell gen
 omics with a “glass-box” interpretable deep learning strategy. First\,
  to chart the transcription factors active during development\, we profile
  gene expression and DNA accessibility at the single-cell level during hum
 an fetal development and in brain organoids. We train deep learning models
  to use DNA sequence to predict epigenome profiles\, and then systematical
 ly interpret what the models learned to extract specific DNA sequences and
  transcription factors that determine cell state. Next\, we extend this st
 rategy to profile post-mortem brains from individuals with schizophrenia o
 r bipolar disorder\, and matched controls\, through the PsychENCODE Consor
 tium. We use deep learning models on these data to predict the effects of 
 noncoding genetic variants on the epigenome. Ultimately\, this work will i
 dentify causal steps in gene regulation and disease.\n\n                  
                                                                      \n\nC
 lick here to download the event poster
GEO:37.430178;-122.176478
LOCATION:Stanford Neurosciences Building
SUMMARY:Brain Resilience Seminar: Christine Ng and Selin Jessa
URL;VALUE=URI:https://events.stanford.edu/event/brain-resilience-seminar-ch
 ristine-ng-and-selin-jessa
END:VEVENT
END:VCALENDAR