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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:An epigenetic code in double-stranded DNA?
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260916T085410Z
UID:tag:localist.com\,2008:EventInstance_50586766994294
DTSTART:20250903T230000Z
DTEND:20250904T003000Z
DESCRIPTION:5-hydroxymethylcytosine encodes regulatory information across D
 NA strands\n\nSpeaker: Dr Jack Hardwick\, University of Bristol\, UK\n\nAb
 stract:\n\nIn mammalian genomes\, cytosine modifications encode a layer of
  regulatory information alongside DNA’s genetic instructions. This infor
 mation is key to our understanding of health\, disease\, and ageing. But i
 ts distribution in double-stranded DNA has remained unclear.\n\nTo address
  this challenge\, we have developed SCoTCH-seq: an accurate and quantitati
 ve\, base-resolution approach to sequence genomes\, together with the two 
 most abundant cytosine modifications—methylation and hydroxymethylation
 —in both strands of individual DNA fragments. We applied this method to 
 embryonic stem cells and found that at CpG sites\, where DNA modifications
  typically occur\, all possible combinations of cytosine can form across t
 he double helix. These ‘CpG states’ have distinct genomic distribution
 s\, including key regions such as enhancers and gene bodies\, and exhibit 
 different relationships with gene expression.\n\nOverall\, our findings in
 dicate that hydroxymethylation and other cytosine variants combine across 
 the DNA double helix to form distinct states of regulatory information.\n\
 nBio:\n\nDr Jack Hardwick is a Lecturer (Assistant Professor) in Biochemis
 try at the University of Bristol\, UK\, where his newly established group 
 seeks to elucidate the role of DNA modifications in the brain.\n\nJack obt
 ained his PhD from the University of Oxford under the guidance of Prof Tom
  Brown\, investigating how chemical modifications to DNA alter its structu
 re and dynamics. Jack then undertook postdoctoral work at the University o
 f Cambridge in the laboratory of Sir Shankar Balasubramanian FRS\, where h
 e developed a new method for sequencing cytosine modifications in double-s
 tranded DNA.\n\nJack’s current work combines sequencing methods developm
 ent\, proteomics\, and biophysics to gain new insights into the function o
 f DNA modifications in neurons. Jack has led multiple collaborations betwe
 en academia and industry\, and his work has been recognised by numerous aw
 ards\, including the Leverhulme Trust Early Career Fellowship and the EPSR
 C Doctoral Prize.
GEO:37.42989;-122.174837
LOCATION:Allen Building\, AllenX\, 101X (Auditorium)
SUMMARY:An epigenetic code in double-stranded DNA?
URL;VALUE=URI:https://events.stanford.edu/event/dr-jack-hardwick-seminar
CATEGORIES:Class/Seminar
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