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X-WR-CALNAME:Neurosciences Seminar: Erin Schuman - The mRNA and protein lan
 dscape at neuronal synapses
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260610T122454Z
UID:tag:localist.com\,2008:EventInstance_47540232303396
DTSTART:20250522T190000Z
DTEND:20250522T200000Z
DESCRIPTION:Join the speaker for coffee\, cookies\, and conversation before
  the talk\, starting at 11:45am.\n\nThe mRNA and protein landscape at neur
 onal synapsesAbstract \n\nNeurons are morphologically complex cells which 
 house thousands of synapses\, but yet contain a single nucleus in the cell
  body.  The proteins present at synapses are the drivers of synaptic trans
 mission and plasticity. I will discuss my lab’s work on the local sourci
 ng and remodeling of synaptic proteomes that arises from the localized tra
 nslation of mRNAs.\n \n\n \n\nErin Schuman\, Ph.D.Max Planck Institute for
  Brain Research\n\nErin Schuman was born in California (1963). Schuman did
  her Bachelor\, PhD and postdoctoral studies at the University of Southern
  California\, Princeton and Stanford\, respectively. In 1993\, she joined 
 the Biology Faculty at Caltech and from 1997-2009\, Schuman was appointed 
 an HHMI investigator. In 2009\, she moved with her husband Gilles Laurent 
 to Frankfurt\, Germany to design and found the new Max Planck Institute fo
 r Brain Research. She is an elected member of EMBO\, the German Academy of
  Sciences Leopoldina\, the American Academy of Arts and Sciences\, and the
  US National Academy of Sciences. She received the Louis-Jeantet Prize for
  Medicine\, the FENSKavli-ALBA Diversity Prize\, the EMBO Women in Science
  Award\, the Rosenstiel Award\, the Brain Prize\, and the Körber Prize. E
 rin Schuman has a long-standing interest molecular and cell biological pro
 cesses that control protein synthesis and degradation in neurons and their
  synapses. The complex morphology of neurons\, with most synapses located 
 hundreds of microns from the cell body\, presents a logistical challenge f
 or the establishment\, maintenance and modification of local synaptic prot
 eomes. Neurons have solved this problem by localizing important cell biolo
 gical machines\, including ribosomes and proteasomes\, within dendrites an
 d axons. Following on the lab’s initial discovery in 1996 that proteins 
 made locally in dendrites are required for synaptic plasticity\, they iden
 tified in molecular detail the mRNA and ribosome population present in neu
 ronal dendrites and axons. In addition\, they have developed new tools to 
 label\, purify\, identify and visualize newly synthesized proteins in neur
 ons and other cells using non-canonical amino acid metabolic labeling\, cl
 ick chemistry\, and mutation of cell-biological enzymes (the BONCAT and FU
 NCAT techniques). Taken together\, the lab’s work has elucidated how gen
 e expression can be regulated in the minute subcellular space of the synap
 se and how decentralization of cell biological machines allows the single 
 neuron to manage subcellular proteomes in a vast volume. The lab’s curre
 nt work focuses on the nature and specialization of mRNA translation and p
 rotein degradation machines and mechanisms in neurons\, including in vivo 
 studies.\n\nVisit Lab Website\n\nHosted by - Xiaoke Chen (Xiaoke Chen Lab)
 \n\n \n\nSign up for Speaker Meet-upsEngagement with our seminar speakers 
 extends beyond the lecture. On seminar days\, invited speakers meet one-on
 -one with faculty members\, have lunch with a small group of trainees\, an
 d enjoy dinner with a small group of faculty and the speaker's host.\n\nIf
  you’re a Stanford faculty member or trainee interested in participating
  in these Speaker Meet-up opportunities\, click the button below to expres
 s your interest. Depending on availability\, you may be invited to join th
 e speaker for one of these enriching experiences.\n\nSpeaker Meet-ups Inte
 rest Form\n\n \n\nAbout the Wu Tsai Neurosciences Seminar SeriesThe Wu Tsa
 i Neurosciences Institute seminar series brings together the Stanford neur
 oscience community to discuss cutting-edge\, cross-disciplinary brain rese
 arch\, from biochemistry to behavior and beyond.\n\nTopics include new dis
 coveries in fundamental neurobiology\; advances in human and translational
  neuroscience\; insights from computational and theoretical neuroscience\;
  and the development of novel research technologies and neuro-engineering 
 breakthroughs.\n\nUnless otherwise noted\, seminars are held Thursdays at 
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LOCATION:Stanford Neurosciences Building | Gunn Rotunda (E241)
SUMMARY:Neurosciences Seminar: Erin Schuman - The mRNA and protein landscap
 e at neuronal synapses
URL;VALUE=URI:https://events.stanford.edu/event/neurosciences-seminar-erin-
 schuman-protein-synthesis-at-the-synapse
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