Rapid change in complex adaptive systems, like marine ecosystems, necessitates responsive and flexible actions across multiple scales. This makes resilience—the capacity to adapt, transform, and persist—critical to the sustainability of ecosystems. But what facilitates resilience in marine social-ecological systems?  This talk explores how resilience in complex marine ecosystems can be facilitated by three key processes: learning through long-term observations, connecting social and ecological information, and collaborating to co-produce knowledge and solutions. These concepts will be explored through a series of three vignettes. The first examines how sustained observations from the world’s oldest marine ecosystem observing program, the California Cooperative Oceanic Fisheries Investigations (CalCOFI), have evolved and informed research and adaptive management. The second assesses the use of social and ecological indicators in U.S. federal environmental and ocean resource agencies to inform holistic, ecosystem-based management. The final vignette introduces a synthetic framework for implementing co-production approaches in ocean sustainability to foster engagement and participatory management. Together, learning, connection, and collaboration can enhance resilience by enabling adaptive, ecosystem-based, participatory marine management. This approach enables flexibility, evidence-based decision-making, and responsiveness to change which can help us to navigate uncertainty and sustain long-term resilience of our interconnected social and ecological systems.