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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:PhD Dissertation Defense: Ali Kight
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260521T072413Z
UID:tag:localist.com\,2008:EventInstance_46365977166015
DTSTART:20240510T170000Z
DTEND:20240510T180000Z
DESCRIPTION:Title: Implantable Devices with Mechanical Intelligence for Hea
 rt Failure Therapy\n\nAbstract: Heart Failure (HF) remains a significant g
 lobal health challenge\, affecting millions and incurring substantial econ
 omic burdens annually. Despite advances in implantable cardiac devices off
 ering mechanical support across HF stages\, mortality rates persist\, sign
 aling the need for innovative approaches.\n\nCentral to HF progression is 
 ventricular remodeling\, driven by abnormal loading and forces sustained b
 y the myocardium. Traditional therapies\, while initially beneficial\, ina
 dvertently lead to abnormal loading conditions that contribute to this rem
 odeling\, exacerbating HF deterioration. Given that remodeling is extremel
 y difficult to reverse\, preserving myocardial function becomes paramount.
 \n\nIn my thesis\, I advocate for a shift towards soft\, dynamically respo
 nsive devices that consider the preservation of myocardial function by reg
 ulating the biomechanical environment. Drawing inspiration from principles
  of mechanical intelligence developed in the field of robotics\, three imp
 lantable devices are developed to address clinical needs in HF at various 
 stages of the condition. \n\nThis presentation will briefly describe the d
 esign\, development\, and evaluation of two mechanical support devices for
  early and end-stage HF. However\, the primary focus will be on the third 
 device\, an implantable sensor for remote patient monitoring\, designed to
  detect subclinical myocardial dysfunction and enable early\, proactive in
 tervention to preserve the myocardium.\n\nPlease contact Madelyn Bernstein
  for the Zoom link
LOCATION:MERL 203
SUMMARY:PhD Dissertation Defense: Ali Kight
URL;VALUE=URI:https://events.stanford.edu/event/phd-dissertation-defense-al
 i-kight
CATEGORIES:PhD Defense
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