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VERSION:2.0
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CALSCALE:GREGORIAN
X-WR-CALNAME:PhD Dissertation Defense: Jerry Yan
X-WR-TIMEZONE:Pacific Time (US & Canada)
BEGIN:VEVENT
DTSTAMP:20260608T235135Z
UID:tag:localist.com\,2008:EventInstance_49799264440521
DTSTART:20250605T180000Z
DTEND:20250605T190000Z
DESCRIPTION:Title: Design Considerations for a Sustained Release Platform t
 o Improve Vaccine Responses\n\nAbstract: Vaccines eliciting rapid\, potent
 \, and durable immune responses remain elusive. While successful vaccine s
 trategies rely on the design of vaccine components\, delivery technologies
  are key contributors to vaccine potency\, quality\, and durability. In th
 e Appel Lab\, we have engineered injectable polymer-nanoparticle (PNP) hyd
 rogels to achieve sustained co-delivery of vaccines. There remains a need 
 to explore the potential design space of PNP hydrogels in the context of c
 linically relevant vaccine characteristics. Such characteristics include t
 he physicochemical identity of vaccine cargo\, dose regimen\, and route of
  administration. In the first half of my thesis\, I present the use of the
  PNP hydrogel system for regimen compression of an inactivated virion-base
 d clinical rabies vaccine. In the second half of my thesis\, I report the 
 compatibility of our hydrogel system across multiple administration routes
 \, including subcutaneous and intramuscular administration\, in a SARS-CoV
 -2 model. Overall\, I demonstrate the versatility of the PNP hydrogel to i
 mprove vaccine immune responses and address current shortcomings of vaccin
 e strategies. \n\nPlease contact leyrec@stanford.edu for the Zoom link.
GEO:37.429138;-122.17552
LOCATION:Shriram Center\, 104
SUMMARY:PhD Dissertation Defense: Jerry Yan
URL;VALUE=URI:https://events.stanford.edu/event/phd-dissertation-defense-je
 rry-yan
CATEGORIES:PhD Defense
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