Dissecting hippocampal circuits operations for navigation and learning - Attila Losonczy

Thursday, November 30, 2017

11:00 am

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Dissecting hippocampal circuits operations for navigation and learning

Attila Losonczy, MD, PhD

Associate Professor, Department of Neuroscience, Columbia University, New York

Host: Matthew Lovett-Barron (Deisseroth Lab)


Learning and remembering where and when salient events occur in space and time are essential for adaptive behaviors. Both spatial navigation and episodic memory have been linked to the mammalian hippocampus, but the detailed mechanisms at cellular and circuit levels remain poorly understood. To address these questions, we use in vivo functional imaging to monitor the activity of identified excitatory, inhibitory and neuromodulatory circuit motifs in the hippocampus of behaving mice during spatial exploration, fear learning and goal-directed learning. The talk will focus on our recent efforts aimed at dissecting functional roles of multimodal microcircuits at the dentate gyrus input and at the CA1 output nodes of the hippocampus. I will summarize how various types of dentate gyrus principal neurons – adult-born and mature granule cells, and hilar mossy cells contribute to context encoding and discrimination. We also monitored activity in deep and superficial subpopulations of CA1 pyramidal cells, and assessed the relationship between sublayer dynamics and learning.  Finally, I will present findings on how goal-oriented learning is supported by disinhibitory GABAergic circuits in CA1. Together, our results demonstrate a functional division of labor among subpopulations of principal neurons during hippocampal-dependent behaviors.

Thursday, November 30, 2017
11:00 am – 12:00 pm
Clark Center Auditorium Map

Seminar Science 

Faculty/Staff, Students
650-497-8019, neuroscience@stanford.edu
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