Local translation and axon survival in touch sensation - Rosalind Segal

Thursday, February 8, 2018

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Local translation and axon survival in touch sensation

Rosalind Segal, MD, Ph.D

Professor, Neurobiology, Harvard Medical School

Host: Aram Raissi (Shatz Lab)


Axons provide the essential long-range connections that establish and maintain complex brain circuitry. However, the mechanisms that regulate axonal viability during development and throughout life are not well understood.  We report that an RNA-binding protein, SFPQ, interacts with multiple mRNAs localized to axons of sensory neurons.  SFPQ promotes the co-assembly of distinct mRNAs into transport granules destined for the Distal axons.  Genetic reduction of SFPQ results in lower levels of target mRNAs in axons, and consequently causes axonal degeneration. Thus SFPQ is a key component of an RNA regulon responsible for neurotrophin-dependent axonal survival.  SFPQ has been implicated in multiple neurologic disorders. Thus, our studies suggest that aberrations in post-transcriptional regulation of key axonal components promote degeneration during early stages of neurologic disease. Accordingly we examine the implications of these findings for degenerative disorders including chemotherapy induced peripheral neuropathy and for ALS.

Thursday, February 8, 2018
12:00 pm – 1:00 pm
Clark Center Auditorium Map

Seminar Science 

Faculty/Staff, Students
650-497-8019, neuroscience@stanford.edu
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