Functional flexibility: Circuit mechanisms of state-dependent regulation in the cortex - Jess Cardin

Thursday, May 24, 2018

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

Functional flexibility: Circuit mechanisms of state-dependent regulation in the cortex

Jess Cardin, PH.D

Associate Professor Term at Yale School of Medicine

Host: Jun Ding

Abstract

The physical components of cortical circuits, cells and synapses, are relatively stable.  However, the operation of those circuits varies on a millisecond timescale with changes in behavioral state and cognition.  Recent work has suggested that this extensive adaptation to changes in context and demand is supported by rapid flexibility in the ‘functional’ circuit, the cells which are participating in circuit operations at any given moment.  One potential mechanism that could promote the functional flexibility of cortical circuits is the diversity of GABAergic interneurons.  Distinct populations of inhibitory interneuron have different intrinsic properties, activity profiles, and synaptic targeting, and are recruited into ongoing network activity under different conditions.  To examine how different populations regulate the evolving pattern of cortical circuit activity, we have explored the developmental and mature roles of interneurons, whose activity is tightly correlated with behavioral state.  We have further examined how interactions among different interneuron populations affect the influence of soma- vs dendrite-targeting inhibition under different behavioral conditions. 

When:
Thursday, May 24, 2018
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Lecture / Reading Humanities Engineering Science 

Audience:
Faculty/Staff, Students
Contact:
650-723-3573, neuroscience@stanford.edu
More info:
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