RNA and DNA binding proteins control the composition of calcium channels in nociceptors in normal and neuropathic pain states - Diane Lipscombe

Thursday, November 1, 2018

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Stanford Neurosciences Institute

Stanford Neurosciences Institute Seminar Series Presents

RNA and DNA binding proteins control the composition of calcium channels in nociceptors in normal and neuropathic pain states 

Diane Lipscombe, PhD

Professor of Neuroscience, Director of the Robert J. and Nancy D. Carney Institute for Brain Science, Thomas J. Watson, Sr. Professor of Science at Brown University

Host: John Huguenard

Abstract

The majority of multi-exon genes are subject to alternative splicing, whereby each gene has the capacity to generate multiple mRNA and protein isoforms depending on cell state. Cell-specific alternative splicing regulates numerous essential cell functions and aberrant splicing is implicated in disease. Voltage-gated CaV2.2 calcium (CaV) channels are subject to extensive alternative splicing. In sensory neurons, these channels control transmission of noxious stimuli at nociceptor terminals in dorsal horn spinal cord. They are major targets of many drugs including morphine, as well as neurotransmitters that activate G-protein coupled receptors to down regulate nociception. Cell-specific alternative splicing in nociceptors regulates CaV2.2 density, sensitive to G protein coupled receptors, trafficking and is disrupted following nerve injury. We now describe the cell-specific mechanisms that regulate the expression and composition of CaV2.2 channel splice isoforms. The coordinated actions of RNA as well as DNA binding proteins generate a family of alternative splice isoforms of CaV2.2 mRNAs in a subset of nociceptors. Splicing is disrupted following peripheral nerve injury potentially contributing to disease pathology.

When:
Thursday, November 1, 2018
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Lecture / Reading Humanities Engineering Science 

Audience:
Faculty/Staff, Students
Contact:
650-723-3573, neuroscience@stanford.edu
More info:
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