Illuminating Stem Cell Trajectories and Cellular Diversity in the Nervous System - John Ngai

Thursday, January 10, 2019

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Wu Tsai Neurosciences Institute

Wu Tsai Neurosciences Institute Seminar Series Presents

Illuminating Stem Cell Trajectories and Cellular Diversity in the Nervous System

John Ngai, PhD

Professor of Neurobiology at UC Berkeley

Host: Aaron Gitler

Abstract

The generation of neuronal diversity in the nervous system requires the specification and differentiation of a multitude of cellular lineages. The specific genetic programs underlying the differentiation of mature neurons from their progenitors remain incompletely characterized, however, in part because of the difficulty in studying neuronal progenitor cells in their native environments. In the vertebrate olfactory system, primary sensory neurons are continuously regenerated throughout adult life via the proliferation and differentiation of multipotent neural stem cells. Upon severe injury, these adult tissue stem cells are activated and go on to reconstitute all of the cellular constituents of this sensory epithelium. The regenerative capacity of the olfactory epithelium therefore represents a powerful and experimentally accessible paradigm for elucidating the mechanisms regulating neural stem cell function. I will present recent studies employing single cell transcriptomics, clonal lineage tracing, and genetic perturbations that together give insights into the genetic programs that both define and regulate olfactory neurogenesis during regeneration. I will also discuss our efforts using CRISPR/Cas9-based genetic engineering to generate genetic tools for studying diverse neuronal subtypes in the mouse brain.

When:
Thursday, January 10, 2019
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Lecture / Reading Engineering Humanities Science 

Audience:
Faculty/Staff, Students
Contact:
650-723-3573, neuroscience@stanford.edu
More info:
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