High-speed and high-resolution imaging of brain activity - Na Ji

Thursday, February 21, 2019

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Wu Tsai Neurosciences Institute

Wu Tsai Neurosciences Institute Seminar Series Presents

High-speed and high-resolution imaging of brain activity

Na Ji, PhD

Associate Professor

UC Berkeley

Host: Jun Ding

Abstract

To understand computation in the brain, one needs to understand the input-output relationships for neural circuits and the anatomical and functional relationships between individual neurons therein. Optical microscopy has emerged as an ideal tool in this quest, as it is capable of recording the activity of neurons distributed over millimeter dimensions with sub-micron spatial resolution. I will describe how we use concepts in astronomy and optics to develop next-generation microscopy methods for imaging neural circuits at higher resolution, greater depth, and faster speed. By shaping the wavefront of the light, we have achieved synapse-level spatial resolution through the entire depth of primary visual cortex, optimized microendoscopes for imaging deeply buried nuclei, and developed a video-rate (30 Hz) volumetric imaging method. We apply these methods to understanding neural circuits, using the mouse primary visual cortex as our model system.  

When:
Thursday, February 21, 2019
12:00 pm – 1:00 pm
Where:
Clark Center Auditorium Map
Tags:

Lecture / Reading Engineering Humanities Science 

Audience:
Faculty/Staff, Students
Contact:
650-723-3573, neuroscience@stanford.edu
More info:
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