Functional dynamics of glutamate transporters - Olga Boudker

Thursday, March 7, 2019

12:00 pm

Clark Center Auditorium Map

Sponsored by:
Wu Tsai Neurosciences Institute

Wu Tsai Neurosciences Institute Seminar Series Presents

Functional dynamics of glutamate transporters

Olga Boudker, PhD

Professor of Physiology and Biophysics

Weill Cornell Medical College

Host: Corianne van Akker (Boxer Lab)


Glutamate transporters are responsible for the uptake of the neurotransmitter glutamate from the synaptic cleft into glial cells in a process driven by the energy of ionic gradients. Extensive studies on a bacterial homologue GltPh have shown that these transporters operate by a so-called elevator mechanism, where a distinct “transport” domain moves the substrate and coupled ions across the membrane. The dynamics of this process determine the rate at which the transporters operate. We aim to understand the nature of the energetic barriers that shape the dynamics and function of these transporters and the means of their rational manipulations. 

Thursday, March 7, 2019
12:00 pm – 1:00 pm
Clark Center Auditorium Map

Lecture / Reading Engineering Humanities Science 

Faculty/Staff, Students
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