Pediatric Grand Rounds (CME) - Emerging Lung Disease in Systemic Juvenile Idiopathic Arthritis

Friday, January 18, 2019

8:00 am

Auditorium (180), Lucile Packard Children's Hospital

Sponsored by:
Pediatrics

Pediatric Grand Rounds (CME)

Vivian Saper, MD - Stanford School of Medicine

Systemic juvenile idiopathic arthritis (sJIA) is an unexplained auto-inflammatory condition initially described in the late 19th century. Pleuritis and pericarditis are known to occur in some children as part of the illness yet parenchymal lung disease has not been a feature. In the past decade, new biologic medications inhibiting potent cytokines IL-1 and IL-6 have gained traction as early therapy.

Session Description:
Systemic juvenile idiopathic arthritis (sJIA) is an unexplained auto-inflammatory condition initially described in the late 19th century. Pleuritis and pericarditis are known to occur in some children as part of the illness yet parenchymal lung disease has not been a feature. In the past decade, new biologic medications inhibiting potent cytokines IL-1 and IL-6 have gained traction as early therapy. Response to treatment with these products has been met with welcome therapeutic success. However, coinciding with the increased use of these drugs, severe and often fatal lung disease has been encountered. Results of an international collection of 61 cases of lung disease found in association with sJIA will be presented. This study illustrates the difficulty of addressing a possible drug related risk occurring in a complicated illness.

Education goals for this session:
- Describe the features traditionally associated with sJIA
- Appreciate that an often fatal lung disease is being increasingly recognized in sJIA
- Be alert to clinical features appearing in association with this lung disease
- Understand difficulties inherent to post marketing drug surveillance in a complex illness

When:
Friday, January 18, 2019
8:00 am – 9:00 am
Where:
Auditorium (180), Lucile Packard Children's Hospital
Tags:

Lecture / Reading Education Health / Wellness Science 

Audience:
Faculty/Staff, Students
Contact:
650-724-1443, pedsgrandrounds@stanford.edu
More info:
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