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Depression Research Clinic Recruiting Non-Depressed Controls for Biological Markers Study
Identifying Biological Markers for Severe Depression
The primary objective of this study is to investigate the biological components of major depression.
We are particularly interested in genetic variation and how it contributes to cortisol (because cortisol is higher in severe depression than miild depression or healthy controls) and how it contributes to clinical symptoms, especially suicidal ideation/behavior and psychosis.
We hope to learn whether there are genetic factors common in depression and their role in symptom presentation, particularly suicidality and psychosis. We aim to better understand the mechanisms of neurocognitive, physiologic and genetic dysfunction in Psychotic Depression and Non-psychotic Depression.
We are focusing on understanding the relationship of genetics to specific aspects of the HPA (hypothalamic-pituitary-adrenal) axis dysregulation in depression. With this knowledge we hope to gain a better understanding and ability to treat clinical symptoms, suicide ideation/behavior, and psychosis in persons with Major Depressive Disorder.
For further details, please see the following link: https://clinicaltrials.gov/ct2/show/NCT01831882
To fill out an online screening as a depressed participant or non-depressed control, please visit the Stanford Depression Research Clinic Screening and apply for our Identifying Biological Markers for Severe Depression study